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Normally the HPA system is characterized by diurnal circadian rhythm. Increasing levels of ACTH stimulate adrenocortical activity resulting in a rise in plasma cortisol buy Deltasone Brand Cheap maximal levels occurring between 2 am and 8 am. This rise in cortisol dampens ACTH production and in turn adrenocortical activity. There is a gradual fall in plasma corticoids during the day with lowest levels occurring about midnight.
It would appear, then, that a disturbance in the diurnal cycle buy Deltasone Brand Cheap maintenance of elevated corticoid values during the night may play a significant role in the development of undesirable corticoid effects. During conventional pharmacologic dose corticosteroid therapy, ACTH production is inhibited with subsequent suppression of cortisol production by the adrenal cortex.
Recovery time for normal HPA activity is variable depending upon the dose and duration of treatment. During this time the patient is vulnerable to any stressful situation.
Further, it has been shown that a single dose of certain corticosteroids will produce adrenocortical suppression for two or more days, Buy Deltasone Brand Cheap. The following should be kept in mind when considering alternate day therapy: Basic principles and indications for corticosteroid therapy should buy Deltasone Brand Cheap. The benefits of ADT should not encourage the indiscriminate use of steroids. ADT is a therapeutic technique primarily designed for patients in whom long-term pharmacologic corticoid therapy is anticipated.
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